RILPL2抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell, Primary antibody: P09156(RILPL2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P09156(RILPL2 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The RILPL2 (Rab Interacting Lysosomal Protein-Like 2) antibody is a tool used to study the RILPL2 protein, a member of the Rab-interacting lysosomal protein family. RILPL2 is implicated in intracellular trafficking and cilium formation through its interaction with Rab GTPases, particularly Rab8 and Rab10. which regulate vesicular transport and membrane dynamics. It plays a role in primary cilia assembly by recruiting ciliary components and modulating microtubule organization. Dysregulation of RILPL2 has been linked to ciliopathies, neurodegenerative disorders, and cancer, making it a subject of interest in cellular and disease research.

The RILPL2 antibody is typically generated using recombinant protein fragments or synthetic peptides to ensure specificity. It is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect RILPL2 expression, localization, and interaction partners in cell lines or tissue samples. Studies utilizing this antibody have revealed RILPL2's involvement in ciliogenesis, cell cycle regulation, and autophagy pathways. Recent research also explores its potential role in cancer progression, particularly in glioblastoma and ovarian cancer, where altered RILPL2 expression correlates with tumor invasiveness. Validation steps, such as knockout controls or siRNA knockdown, are critical to confirm antibody specificity due to homology within the RILP protein family.