CSRP3抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human heart tissue, Rat heart tissue and Mouse heart tissue lysates, Primary antibody: P09152(CSRP3 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P09152(CSRP3 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P09152(CSRP3 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The cysteine and glycine-rich protein 3 (CSRP3), also known as muscle LIM protein (MLP), is a key member of the LIM-only protein family involved in cellular structure, signaling, and mechanosensation. Primarily expressed in cardiac and skeletal muscle, CSRP3 localizes to the cytoplasm and nucleus, interacting with cytoskeletal components (e.g., α-actinin, titin) and transcription factors to regulate muscle differentiation, hypertrophy, and stress response pathways. Its LIM domains mediate protein-protein interactions critical for maintaining sarcomere integrity and transducing mechanical signals.

CSRP3 antibodies are essential tools for studying its role in cardiovascular diseases. Research links CSRP3 mutations or dysregulation to cardiomyopathies, including dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), as well as heart failure. Antibodies targeting CSRP3 enable detection of its expression levels, subcellular localization, and interactions via techniques like Western blot, immunohistochemistry, and co-immunoprecipitation. Studies using CSRP3-deficient mice have revealed its importance in cardiac adaptation to mechanical stress, while human clinical data suggest its potential as a biomarker for disease progression.

Due to CSRP3's evolutionary conservation across vertebrates, antibodies often exhibit cross-reactivity in preclinical models. Ongoing research explores its therapeutic targeting to modulate pathological cardiac remodeling or enhance regenerative pathways.