RHEBL1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P09149(RHEBL1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09149(RHEBL1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The RHEBL1 (Ras Homolog Enriched in Brain-Like 1) antibody is a tool used to study the RHEBL1 protein, a small GTPase belonging to the Ras superfamily. RHEBL1 shares structural homology with Rheb (Ras homolog enriched in brain) and plays a role in regulating cellular processes such as cell growth, autophagy, and mTORC1 (mechanistic target of rapamycin complex 1) signaling. Unlike Rheb, RHEBL1 is less characterized but is implicated in unique pathways, including interactions with lysosomal function and response to nutrient stress. Its expression is tissue-specific, with higher levels observed in the brain, suggesting potential roles in neurological functions or disorders.

Antibodies targeting RHEBL1 enable researchers to investigate its expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. These studies are critical for understanding its regulatory mechanisms, particularly in mTORC1 activation, which influences cell proliferation and metabolism. Dysregulation of RHEBL1 has been linked to pathological conditions, including cancer and neurodegenerative diseases, making it a potential therapeutic target. However, research remains ongoing to clarify its precise biological roles and cross-talk with related pathways. Commercial RHEBL1 antibodies vary in specificity, requiring validation using knockout controls to ensure reliability in experimental models.