EEF1E1抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-6: A549 cell, Jurkat cell, Human testis tissue, 293T cell, Hepg2 cell and A431 cell, Primary antibody: P09146(EEF1E1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09146(EEF1E1 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P09146(EEF1E1 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The eukaryotic translation elongation factor 1 epsilon-1 (EEF1E1), also known as eEF1Bα or eEF1B1. is a subunit of the eEF1B complex involved in protein synthesis. It functions as a guanine nucleotide exchange factor (GEF) for eEF1A, facilitating the replacement of GDP with GTP to reactivate eEF1A during the elongation phase of translation. EEF1E1 is ubiquitously expressed and plays a critical role in maintaining translational fidelity and efficiency.

Antibodies targeting EEF1E1 are valuable tools for studying its expression, localization, and interaction partners in various biological contexts. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to explore EEF1E1's regulatory roles in cellular processes, including stress responses, cell cycle control, and apoptosis. Dysregulation of EEF1E1 has been implicated in diseases such as cancer, neurodegenerative disorders, and viral infections, making its antibodies essential for mechanistic research.

Additionally, EEF1E1 antibodies help investigate its non-canonical functions, such as involvement in DNA repair and transcriptional regulation. Studies have linked EEF1E1 overexpression to tumorigenesis in certain cancers, while reduced levels are associated with neurological pathologies. These antibodies also aid in identifying post-translational modifications or isoforms that modulate EEF1E1 activity. Commercial EEF1E1 antibodies are typically raised in rabbits or mice, validated for specificity across human, mouse, and rat models, supporting cross-species translational research.