CIAO2A抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal intestines tissue , Primary antibody: P09140(CIAO2A Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

**Background of CIAO2A Antibody**

The CIAO2A (Cytosolic Iron-Sulfur Assembly Component 2A) antibody is a tool used to study the CIAO2A protein, a key component of the cytosolic iron-sulfur cluster assembly (CIA) machinery. Iron-sulfur (Fe-S) clusters are essential cofactors for numerous enzymes involved in critical cellular processes, including DNA repair, metabolic pathways, and redox regulation. The CIA pathway, localized in the cytosol and nucleus, is responsible for assembling and inserting Fe-S clusters into target apoproteins. CIAO2A, along with CIAO1 and MMS19. forms the CIA2A-MMS19-CIAO1 complex, which facilitates the transfer of Fe-S clusters to specific client proteins.

CIAO2A is particularly crucial for the maturation of enzymes like DNA polymerases and helicases, linking Fe-S cluster biogenesis to genome stability and cell cycle progression. Dysregulation of CIAO2A has been implicated in diseases such as cancer and neurodegenerative disorders, where Fe-S cluster metabolism is often compromised.

The CIAO2A antibody enables researchers to detect and quantify CIAO2A expression in various tissues and cell lines using techniques like Western blotting, immunofluorescence, or immunohistochemistry. It aids in exploring the protein’s role in Fe-S cluster assembly, its interaction partners, and its broader implications in cellular homeostasis and disease mechanisms. Studies utilizing this antibody contribute to understanding how disruptions in Fe-S biogenesis impact human health, offering potential therapeutic insights.