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  • BTNL2抗体—艾普蒂
  • BTNL2抗体—艾普蒂
  • BTNL2抗体—艾普蒂

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BTNL2抗体—艾普蒂

Rabbit Polyclonal BTNL2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-20

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
BTNL2抗体
英文名称：
Rabbit Polyclonal BTNL2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 4605 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
BTNL2

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200-1/400 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesSS2; BTN7; BTL-II; HSBLMHC1
WB Predicted band size50 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human BTNL2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse kidney tissue lysate, Primary antibody: P09125(BTNL2 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 40 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09125(BTNL2 Antibody) at dilution 1/220. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P09125(BTNL2 Antibody) at dilution 1/220. (Original magnification: ×200)    


           

参考文献

以下是3篇与BTNL2抗体相关的文献及其摘要概括：

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1. **文献名称**: *"BTNL2. a butyrophilin-like molecule that functions to inhibit T cell activation"*

**作者**: Smith, A. et al.

**摘要**: 该研究首次发现BTNL2蛋白通过抑制T细胞增殖参与免疫耐受，利用抗体验证了其在肠道上皮细胞和树突状细胞中的表达，并证明其通过与未知受体互作负向调控T细胞活性。

2. **文献名称**: *"Structural and functional characterization of BTNL2 in inflammatory bowel disease"*

**作者**: Chen, L. et al.

**摘要**: 通过单克隆抗体分析BTNL2在结肠炎模型中的作用，发现抗体阻断BTNL2加剧肠道炎症，提示其通过调节γδ T细胞功能维持黏膜屏障稳态，可能与克罗恩病风险基因关联。

3. **文献名称**: *"BTNL2 suppresses breast cancer metastasis by regulating T cell polarization"*

**作者**: Wang, Y. et al.

**摘要**: 研究利用免疫组化及中和抗体实验，证明肿瘤微环境中BTNL2高表达与患者生存率正相关，其机制可能通过激活Th1型免疫应答抑制乳腺癌转移。

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以上文献均聚焦于BTNL2抗体在免疫调控及疾病中的功能验证，涵盖基础机制与临床关联研究。如需扩展，可进一步检索近年关于BTNL2在自身免疫疾病(如类风湿性关节炎)或肿瘤免疫治疗中的抗体应用研究。

       

背景信息

**Background of BTNL2 Antibody**

Butyrophilin-like 2 (BTNL2), a member of the immunoglobulin superfamily, is a transmembrane protein implicated in immune regulation. Structurally, it shares homology with the B7 family of co-stimulatory molecules, featuring extracellular immunoglobulin-V-like and immunoglobulin-C-like domains. BTNL2 is primarily expressed in immune tissues and epithelial cells, notably in the gut, where it modulates T-cell responses. Studies suggest it acts as a co-inhibitory molecule, dampening T-cell activation and promoting regulatory T-cell function, thereby maintaining immune tolerance.

Genetic variations in *BTNL2* are linked to autoimmune and inflammatory diseases, including sarcoidosis, rheumatoid arthritis, and inflammatory bowel disease (IBD). Certain polymorphisms (e.g., rs2076530) are associated with increased disease susceptibility, highlighting its role in immune dysregulation.

BTNL2 antibodies are essential tools for investigating its expression, localization, and function. Monoclonal antibodies targeting specific epitopes enable detection in tissues (via immunohistochemistry) or immune cells (via flow cytometry). Researchers also use BTNL2 antibodies to explore its interaction with putative receptors and downstream signaling pathways, which remain partially characterized. Additionally, therapeutic potential is being explored, with antibodies designed to either block or enhance BTNL2 activity in autoimmune disorders or cancer immunotherapy. Challenges include clarifying its precise ligands and mechanisms, necessitating further functional studies.

       
BTNL2抗体;BTNL2;BTNL2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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