GH1抗体

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of Hela cells using GH1 mouse mAb (green) and negative control (red).    

  
  

The GH1 antibody is a specialized immunoglobulin designed to target and detect growth hormone 1 (GH1), a protein encoded by the *GH1* gene in humans. GH1. also known as pituitary growth hormone, is a 22 kDa polypeptide synthesized and secreted by somatotropic cells in the anterior pituitary gland. It plays a critical role in regulating growth, metabolism, and cellular repair through interactions with the growth hormone receptor (GHR), primarily in the liver and other tissues. Dysregulation of GH1 is linked to disorders such as growth hormone deficiency (GHD), gigantism, and acromegaly.

GH1 antibodies are widely utilized in research and diagnostics to quantify GH1 levels in serum, tissues, or cell cultures via techniques like ELISA, Western blotting, and immunohistochemistry. These antibodies are essential for studying GH1 expression patterns, secretion dynamics, and their correlation with pathological conditions. Monoclonal GH1 antibodies offer high specificity, recognizing a single epitope, while polyclonal variants detect multiple epitopes, enhancing sensitivity in diverse experimental setups.

Clinically, GH1 antibodies are employed to monitor recombinant growth hormone (rhGH) therapy in patients with GHD or Turner syndrome, ensuring appropriate dosing and assessing treatment efficacy. Additionally, they aid in differentiating pituitary adenoma subtypes. Recent advancements in antibody engineering have improved affinity and reduced cross-reactivity with structurally similar hormones like prolactin. Despite their utility, challenges remain in standardizing assays to account for GH1 isoforms and pulsatile secretion patterns. Overall, GH1 antibodies remain indispensable tools in both mechanistic studies and translational applications.