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Z-R-K-AOMK
Z-R-K-AOMK
Z-R-K-AOMK
Z-R-K-AOMK
询价
1mg
起订
10mg
起订
100mg
起订
江西 更新日期：2025-10-20
产品详情:
- 中文名称：
- Z-R-K-AOMK
- 英文名称：
- Z-R-K-AOMK
- CAS号：
- 2810056-57-4
- 品牌：
- TanzhenBio
- 产地：
- 江西赣州
- 保存条件：
- -20℃
- 纯度规格：
- 98%
- 产品类别：
- CMK修饰肽
- 别名：
- Z-R-K-AOMK
- 主要用途：
- The peptide derivative Z-Arg-Lys-AOMK (1) was developed in our laboratories as a neutral pH-selective inhibitor of cathepsin B (Cat.B).5 Cat.B is believed to be released upon cellular injury from acidic lysosomes into the neutral pH cytoplasm and initiate and mediate inappropriate proteolytic degradation. Such sequelae are thought to be relevant to the pathogenesis observed with traumatic brain injury and neuropathies such as Alzheimer’s Disease. Our ongoing in vivo evaluations of Z-Arg-Lys-AOMK for its potential neurotherapeutic potential necessitated the scaled-up synthesis of this inhibitor.5 Upon embarking on this endeavor, we encountered several problems with the methodology employed in the previously published synthesis (Figure 1), which utilized solid-phase peptide synthesis and produced insufficient amounts of Z-Arg-Lys-AOMK
- 靶点：
- The peptide derivative Z-Arg-Lys-AOMK (1) was developed in our laboratories as a neutral pH-selective inhibitor of cathepsin B (Cat.B).5 Cat.B is believed to be released upon cellular injury from acidic lysosomes into the neutral pH cytoplasm and initiate and mediate inappropriate proteolytic degradation. Such sequelae are thought to be relevant to the pathogenesis observed with traumatic brain injury and neuropathies such as Alzheimer’s Disease. Our ongoing in vivo evaluations of Z-Arg-Lys-AOMK for its potential neurotherapeutic potential necessitated the scaled-up synthesis of this inhibitor.5 Upon embarking on this endeavor, we encountered several problems with the methodology employed in the previously published synthesis (Figure 1), which utilized solid-phase peptide synthesis and produced insufficient amounts of Z-Arg-Lys-AOMK
- 生物作用：
- The peptide derivative Z-Arg-Lys-AOMK (1) was developed in our laboratories as a neutral pH-selective inhibitor of cathepsin B (Cat.B).5 Cat.B is believed to be released upon cellular injury from acidic lysosomes into the neutral pH cytoplasm and initiate and mediate inappropriate proteolytic degradation. Such sequelae are thought to be relevant to the pathogenesis observed with traumatic brain injury and neuropathies such as Alzheimer’s Disease. Our ongoing in vivo evaluations of Z-Arg-Lys-AOMK for its potential neurotherapeutic potential necessitated the scaled-up synthesis of this inhibitor.5 Upon embarking on this endeavor, we encountered several problems with the methodology employed in the previously published synthesis (Figure 1), which utilized solid-phase peptide synthesis and produced insufficient amounts of Z-Arg-Lys-AOMK
- 应用：
- The peptide derivative Z-Arg-Lys-AOMK (1) was developed in our laboratories as a neutral pH-selective inhibitor of cathepsin B (Cat.B).5 Cat.B is believed to be released upon cellular injury from acidic lysosomes into the neutral pH cytoplasm and initiate and mediate inappropriate proteolytic degradation. Such sequelae are thought to be relevant to the pathogenesis observed with traumatic brain injury and neuropathies such as Alzheimer’s Disease. Our ongoing in vivo evaluations of Z-Arg-Lys-AOMK for its potential neurotherapeutic potential necessitated the scaled-up synthesis of this inhibitor.5 Upon embarking on this endeavor, we encountered several problems with the methodology employed in the previously published synthesis (Figure 1), which utilized solid-phase peptide synthesis and produced insufficient amounts of Z-Arg-Lys-AOMK
公司简介
南昌探真生物技术有限公司
主要业务：多肽服务 ，肽核酸合成
| 成立日期 | (7年) |
| 注册资本 | 300万人民币 |
| 员工人数 | 10-50人 |
| 年营业额 | ￥ 100万-300万 |
| 经营模式 | 贸易,工厂,试剂,定制,服务 |
| 主营行业 | 生物活性小分子,有机合成试剂,氨基糖苷类 |
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