（色氨酸63，色氨酸64）-补体C3a片段（63-67）/130154-64-2/(Trp63,Trp64)-C3a(63-77)

Product Name：(Trp63,Trp64)-C3a(63-77) 

CAS No.：130154-64-2

Synonyms：（色氨酸63，色氨酸64）-补体C3a片段（63-67）

Catalog No.：LT-LS006

Brand：Go Top peptide（杭州固拓）

Description：(Trp63,Trp64)-C3a(63-77)是合成C3a类似肽。可在人中性粒细胞及表达hC3aR或mC3aR的RBL - 2H3细胞中刺激Ca²⁺通量，EC50分别为9.5、2.0和0.8nM。作为补体3a拮抗剂，其生物效力在测试肽中最强，活性是天然C3a的12 - 15倍，该强效通过引入Trp - Trp等大体积疏水基团实现，该基团与受体疏水位点结合更强。

(Trp63, Trp64)-C3a(63-77) is a synthetic C3a-like peptide. It can stimulate Ca²⁺ flux in human neutrophils and RBL - 2H3 cells expressing hC3aR or mC3aR, with EC50 values of 9.5 nM, 2.0 nM and 0.8 nM respectively. As a complement 3a antagonist, it shows the highest biological potency among tested peptides, 12 - 15 times that of natural C3a. This potency is achieved by introducing bulky hydrophobic groups like Trp - Trp, which bind more strongly to receptor hydrophobic sites.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

申明：产品仅供科研使用

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