CHAT抗体;CHAT Antibody—艾普蒂

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     Western blot analysis of CHAT expression in SH-SY5Y cell lysate.    

  
  

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     Immunofluorescent analysis using the Antibody at 1:50 dilution.    

  
  

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     Immunofluorescent analysis using the Antibody at 1:150 dilution.    

  
  

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     Immunofluorescent analysis using the Antibody at 1:50 dilution.    

  
  

**Background of CHAT Antibodies**

Choline acetyltransferase (CHAT) is a critical enzyme responsible for synthesizing acetylcholine (ACh), a key neurotransmitter involved in neuromuscular signaling, cognitive functions, and autonomic nervous system regulation. CHAT antibodies target this enzyme and are primarily studied in two contexts: research and clinical diagnostics.

In research, CHAT antibodies are widely used as immunohistochemical markers to identify cholinergic neurons in the brain and peripheral nervous system, aiding studies on neurodegenerative diseases (e.g., Alzheimer’s) and cholinergic circuitry. They also help assess CHAT expression in conditions like myasthenic syndromes or neurodevelopmental disorders.

Clinically, anti-CHAT antibodies are associated with autoimmune and paraneoplastic disorders. For instance, they are detected in some patients with autoimmune autonomic ganglionopathy (AAG), causing dysautonomia, or in rare cases of congenital myasthenic syndromes due to CHAT gene mutations. Additionally, these antibodies may link to cancer-related neurological syndromes, where immune responses mistakenly attack neuronal CHAT.

However, anti-CHAT antibodies are less common than other neural antibodies (e.g., anti-AChR), making their detection valuable for diagnosing atypical cases. Their presence often prompts further investigation into underlying malignancies or autoimmune etiologies. Overall, CHAT antibodies serve as vital tools in both understanding cholinergic biology and unraveling complex neurological pathologies.