CACNA1D抗体;CACNA1D Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P11614(CACNA1D Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11614(CACNA1D Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The CACNA1D gene encodes the α1D subunit of voltage-gated calcium channels (CaV1.3), which mediate calcium ion influx in excitable cells, influencing processes like neurotransmission, hormone secretion, and muscle contraction. CACNA1D antibodies are immunological tools designed to detect and study this subunit, widely used in research to investigate its expression, localization, and functional roles in tissues. These antibodies are critical for techniques such as Western blotting, immunohistochemistry, and immunofluorescence, enabling visualization of CaV1.3 distribution in the brain, endocrine cells, and cardiovascular system.

Dysregulation of CACNA1D has been linked to neurological disorders (e.g., Parkinson’s disease, autism spectrum disorders), cardiovascular conditions, and endocrine tumors like aldosterone-producing adenomas. Antibodies against CACNA1D aid in exploring its pathological mechanisms, including abnormal calcium signaling and channelopathies. Recent studies also highlight its role in insulin secretion and blood pressure regulation, expanding potential therapeutic targets.

Commercial CACNA1D antibodies vary in specificity, with validation often performed using knockout models or overexpression systems. Researchers must optimize protocols to address cross-reactivity with homologous subunits (e.g., CaV1.2). As interest in calcium channel biology grows, CACNA1D antibodies remain essential for dissecting its contributions to physiology and disease.