BOD1抗体;BOD1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P11604(BOD1 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11604(BOD1 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

BOD1 (Biorientation Defective 1) is a conserved protein involved in regulating chromosome segregation during mitosis, primarily by interacting with the Aurora B kinase complex and modulating its activity. It plays a critical role in ensuring proper attachment of microtubules to kinetochores and correcting erroneous spindle-kinetochore connections, thereby maintaining genomic stability. Dysregulation of BOD1 has been implicated in mitotic errors, aneuploidy, and potential links to developmental disorders or cancer.

BOD1 antibodies are essential tools for studying its expression, localization, and function in cell cycle dynamics. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate BOD1’s interaction partners, phosphorylation status, and role in spindle assembly checkpoint signaling. Recent studies also explore BOD1’s involvement in neurodevelopment, as mutations or altered expression may contribute to conditions like autism spectrum disorders and microcephaly. Commercial BOD1 antibodies are typically raised against specific epitopes in human or murine BOD1. with validation in knockout models to ensure specificity. However, challenges remain in standardizing antibody performance across experimental conditions, particularly given BOD1’s low molecular weight (~20 kDa) and potential cross-reactivity with homologous proteins. Ongoing research continues to clarify its dual roles in mitosis and non-mitotic processes, such as neuronal differentiation.