MYB抗体;MYB Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: SKOV3 and HepG2 cell lysates, Primary antibody: P11591(MYB Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds    

  
  

MYB antibodies are immunological tools used to detect and study MYB proteins, a family of transcription factors critical for cellular processes like proliferation, differentiation, and apoptosis. The MYB family includes three members: c-MYB, A-MYB, and B-MYB, each characterized by a conserved DNA-binding domain. c-MYB, the most extensively studied, is essential for hematopoiesis and stem cell maintenance, while A-MYB and B-MYB play roles in specific tissues like the mammary gland and germ cells. Dysregulation of MYB proteins, particularly c-MYB, is linked to cancers such as leukemia, breast cancer, and colorectal cancer, where overexpression drives oncogenic signaling.

MYB antibodies are employed in research to analyze MYB expression levels, subcellular localization, and interactions via techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation. Their diagnostic potential lies in identifying MYB overexpression in tumors, aiding cancer classification and prognosis. Additionally, they facilitate therapeutic development, as MYB is explored as a drug target. For instance, inhibitors disrupting MYB-DNA binding or degrading MYB mRNA are under investigation.

Despite challenges in targeting transcription factors, MYB antibodies remain pivotal in unraveling MYB's role in both normal physiology and disease, offering insights for precision oncology and biomarker discovery.