ASIC1抗体;ASIC1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11585(ASIC1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11585(ASIC1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

Acid-sensing ion channel 1 (ASIC1) is a proton-gated cation channel belonging to the DEG/ENaC superfamily, primarily expressed in the central and peripheral nervous systems. It plays a critical role in detecting extracellular acidification, a hallmark of ischemic stroke, inflammation, and tissue injury. ASIC1 exists as two splice variants (ASIC1a and ASIC1b) with distinct tissue distributions and pH sensitivities. ASIC1a, the dominant isoform in the brain, is permeable to Ca²⁺ and contributes to acidosis-mediated neuronal damage, synaptic plasticity, and pain perception.

ASIC1 antibodies are essential tools for studying the channel’s expression, localization, and function. They enable detection of ASIC1 proteins in Western blotting, immunohistochemistry, and immunofluorescence, aiding research on its role in neurological disorders (e.g., stroke, epilepsy) and chronic pain. Specific antibodies targeting extracellular or intracellular epitopes help differentiate between isoforms and assess post-translational modifications. Studies using ASIC1 antibodies have revealed its upregulation in pathological conditions, such as neuroinflammation and neurodegeneration, highlighting its therapeutic potential. Inhibitors or modulators targeting ASIC1. validated using these antibodies, are explored for treating ischemic brain injury and inflammatory pain. However, challenges remain in ensuring antibody specificity due to structural similarities among ASIC subunits. Overall, ASIC1 antibodies are pivotal in advancing understanding of pH-sensitive signaling mechanisms and their pathophysiological implications.