ARL3抗体;ARL3 Antibody—艾普蒂

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     Gel: 15%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse brain tissue, 231 cells, A375 cells, Primary antibody: P11582(ARL3 Antibody) at dilution 1/433, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

The ADP-ribosylation factor-like protein 3 (ARL3) is a small GTPase belonging to the ARF/ARL family, which regulates membrane trafficking, cytoskeletal dynamics, and ciliary functions. ARL3 plays a critical role in lipidated protein trafficking within photoreceptors and cilia, facilitating the localization of proteins like rhodopsin and nephrocystin-3. Mutations in ARL3 are linked to inherited retinal dystrophies and ciliopathies, underscoring its importance in sensory and developmental processes.

ARL3 antibodies are essential tools for studying its expression, localization, and interactions. They enable detection of ARL3 in tissues (e.g., retina, kidney) and cell lines via techniques like Western blot, immunohistochemistry, and immunofluorescence. These antibodies also aid in investigating ARL3's GTPase activity, its regulation by guanine nucleotide exchange factors (GEFs), and its role in cargo release through interactions with effector proteins like UNC119 and PDE6D. Research using ARL3 antibodies has advanced understanding of ciliary signaling defects and potential therapeutic targets for related diseases. Commercial ARL3 antibodies are typically validated for specificity, often targeting conserved regions such as the N-terminus or GTP-binding domains.