BNIP2抗体;BNIP2 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P11576(BNIP2 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P11576(BNIP2 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The BNIP2 (BCL2/adenovirus E1B 19 kDa interacting protein 2) antibody is a tool used to detect and study the BNIP2 protein, a member of the BNIP family involved in regulating cellular processes such as apoptosis, autophagy, and mitochondrial dynamics. BNIP2 interacts with BCL-2 family proteins, which are critical in controlling programmed cell death, and may also engage with Rho GTPase signaling pathways to influence cytoskeletal organization and cell migration. Its role in hypoxia-related pathways, particularly through interactions with HIF-1α, has drawn interest in cancer research, where dysregulated BNIP2 expression is linked to tumor progression and metastasis.

The BNIP2 antibody is widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and function in various tissues and disease models. Researchers employ it to explore BNIP2's involvement in diseases such as cancer, cardiovascular disorders, and neurodegenerative conditions. Commercial BNIP2 antibodies are typically developed in hosts like rabbits or mice, with validation for specificity and cross-reactivity across species. Ongoing studies aim to clarify its dual roles in pro-survival and pro-death mechanisms, highlighting its potential as a therapeutic target or biomarker in precision medicine.