COX5A抗体;COX5A Antibody—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell, Primary antibody: P11569(COX5A Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 7 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11569(COX5A Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P11569(COX5A Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The cytochrome c oxidase subunit 5A (COX5A) is a nuclear-encoded subunit of cytochrome c oxidase (Complex IV), the terminal enzyme in the mitochondrial electron transport chain (ETC). As a key component of Complex IV, COX5A plays a critical role in catalyzing the transfer of electrons from cytochrome c to molecular oxygen, coupled with proton translocation across the inner mitochondrial membrane to support ATP synthesis. Dysregulation of COX5A has been implicated in mitochondrial dysfunction, which is associated with various diseases, including neurodegenerative disorders, metabolic syndromes, and cancers.

COX5A-specific antibodies are essential tools for investigating its expression, localization, and functional interactions in cellular and disease contexts. These antibodies enable the detection of COX5A protein levels via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in studies of mitochondrial physiology and pathology. Researchers use COX5A antibodies to explore tissue-specific expression patterns, assess responses to metabolic stressors (e.g., hypoxia or oxidative stress), and examine correlations between COX5A dysregulation and diseases like Alzheimer's, Parkinson's, or colorectal cancer. Commercial COX5A antibodies are typically raised in hosts such as rabbits or mice, targeting specific epitopes with validated specificity. Their applications extend to diagnostic research and therapeutic target validation, emphasizing COX5A's role in cellular energy homeostasis and disease mechanisms.