STAT2抗体;STAT2 Antibody—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: PC3 cells, Primary antibody: P11565(STAT2 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P11565(STAT2 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

**Background of STAT2 Antibody**

STAT2 (Signal Transducer and Activator of Transcription 2) is a member of the STAT protein family, which plays a critical role in mediating cellular responses to cytokines and interferons (IFNs). Specifically, STAT2 is essential for type I and III IFN signaling pathways. Upon IFN stimulation, STAT2 is phosphorylated by receptor-associated JAK kinases, leading to its dimerization with STAT1 and association with IRF9 to form the ISGF3 (IFN-stimulated gene factor 3) complex. This complex translocates to the nucleus, binding IFN-stimulated response elements (ISREs) to activate transcription of interferon-stimulated genes (ISGs), which orchestrate antiviral and immune regulatory responses.

STAT2 antibodies are valuable tools for studying its expression, activation, and interactions in immune signaling. They are widely used in techniques like Western blotting, immunoprecipitation, immunofluorescence, and flow cytometry to assess STAT2 protein levels, phosphorylation status (e.g., Tyr690), and subcellular localization. Dysregulation of STAT2 has been implicated in viral evasion mechanisms, autoimmune disorders, and cancer, making these antibodies crucial for research into disease mechanisms and therapeutic targeting.

As STAT2-deficient models show impaired antiviral defense, antibodies against STAT2 also aid in validating knockout systems or studying crosstalk with other signaling pathways (e.g., STAT1. STAT3). Commercial STAT2 antibodies are typically validated for specificity across human, mouse, and rat samples, ensuring broad applicability in preclinical and clinical research.