AHR抗体;AHR Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11564(AHR Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that plays a critical role in mediating cellular responses to environmental pollutants, such as dioxins and polycyclic aromatic hydrocarbons. It regulates genes involved in xenobiotic metabolism (e.g., CYP1A1), immune modulation, and cellular homeostasis. AHR antibodies are essential tools for studying its expression, activation, and downstream signaling. Researchers use these antibodies in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to detect AHR protein levels, subcellular localization, and DNA-binding activity.

AHR's involvement in immune regulation, cancer progression, and metabolic diseases has driven interest in therapeutic targeting. Antibodies help elucidate its dual role in contexts like cancer (pro-tumor vs. anti-tumor effects) or autoimmune disorders. Recent studies also explore AHR's interaction with microbiome-derived metabolites, expanding its relevance to gut immunity and inflammation. Commercial AHR antibodies vary in specificity, targeting different epitopes (e.g., N-terminal vs. C-terminal regions), requiring validation for experimental models. Challenges remain in distinguishing canonical AHR pathways from ligand- or cell-type-specific responses, underscoring the need for reliable antibody tools to advance mechanistic and translational research.