SENP1抗体;SENP1 Antibody—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: K562 cells, Primary antibody: P11531(SENP1 Antibody) at dilution 1/1500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11531(SENP1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11531(SENP1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The sentrin-specific protease 1 (SENP1) antibody is a crucial tool for studying the regulation of SUMO (Small Ubiquitin-like Modifier) modification, a post-translational process involved in diverse cellular functions. SENP1. a member of the SENP protease family, catalyzes the cleavage of SUMO proteins from conjugated substrates, reversing SUMOylation and maintaining dynamic equilibrium in SUMO signaling. This enzyme preferentially processes SUMO-1 and SUMO-2/3 precursors and deconjugates SUMOylated proteins, influencing processes like transcriptional regulation, cell cycle progression, and DNA repair. Dysregulation of SENP1 has been linked to cancers, cardiovascular diseases, and neurological disorders, making it a research focus in disease mechanisms.

SENP1 antibodies are designed to detect endogenous SENP1 proteins in applications such as Western blotting, immunoprecipitation, and immunofluorescence. These antibodies typically target specific epitopes within SENP1's conserved catalytic domain or regulatory regions, enabling researchers to study its expression, localization, and interaction partners. Validation of SENP1 antibodies includes testing in knockout cell lines or tissues to confirm specificity. As SENP1 activity modulates critical pathways like HIF-1α and NF-κB signaling, its antibody serves as a vital reagent for investigating SUMOylation dynamics in both physiological and pathological contexts, offering insights into therapeutic targeting strategies.