NPAP1抗体;NPAP1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11525(NPAP1 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

**Background of NPAP1 Antibody**

The NPAP1 (Nucleus Accumbens-Associated Protein 1) antibody is a tool used to detect NPAP1. a protein encoded by the *NPAP1* gene located within the Prader-Willi syndrome (PWS) critical region on human chromosome 15q11-q13. This gene is part of a cluster of imprinted genes predominantly expressed from the paternal allele. NPAP1 is speculated to play roles in neuronal development and synaptic function, though its precise molecular mechanisms remain unclear.

Interest in NPAP1 stems from its association with PWS, a neurodevelopmental disorder characterized by hypotonia, hyperphagia, and cognitive impairments. Loss of paternal *NPAP1* expression due to deletions or imprinting defects contributes to PWS pathogenesis. NPAP1 antibodies are thus utilized in research to study protein expression patterns in neural tissues, particularly the nucleus accumbens, a brain region linked to reward and motivation.

These antibodies are critical for techniques like Western blotting, immunohistochemistry, and immunofluorescence, enabling visualization of NPAP1 distribution in cellular and animal models. Studies using NPAP1 antibodies aim to clarify its role in neurodevelopmental pathways and its potential interaction with other PWS-related proteins. However, research is limited by the gene's recent identification and overlapping genomic features with noncoding RNAs in the PWS region. Further investigations are needed to unravel NPAP1's functional significance and therapeutic relevance in neurodevelopmental disorders.