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  • THBS1抗体;THBS1 Antibody—艾普蒂
  • THBS1抗体;THBS1 Antibody—艾普蒂
  • THBS1抗体;THBS1 Antibody—艾普蒂

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THBS1抗体;THBS1 Antibody—艾普蒂

Rabbit Polyclonal THBS1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-26

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：nuodina88@163.com

产品详情:

中文名称：
THBS1抗体
英文名称：
Rabbit Polyclonal THBS1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 6112 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
THBS1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesTSP; THBS; TSP1; TSP-1; THBS-1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human THBS1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11524(THBS1 Antibody) at dilution 1/60. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P11524(THBS1 Antibody) at dilution 1/60. (Original magnification: ×200)    


           

参考文献

以下是3篇关于THBS1抗体的参考文献(摘要为概括内容)：

1. **"Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level"**

*作者：Greenaway J. et al.*

摘要：研究利用THBS1抗体分析其在血管生成中的作用，发现THBS1通过结合VEGF受体抑制内皮细胞信号通路，揭示了其在肿瘤微环境中的调控机制。

2. **"THBS1 expression in colorectal cancer: A prognostic biomarker associated with immune infiltration"**

*作者：Wang L. et al.*

摘要：通过免疫组化(使用THBS1抗体)发现，THBS1在结直肠癌中高表达，其水平与患者预后及CD8+ T细胞浸润负相关，提示其作为免疫治疗靶点的潜力。

3. **"Thrombospondin-1 regulates mitochondrial metabolism via CD47 signaling in macrophages"**

*作者：Mazzieri R. et al.*

摘要：研究采用THBS1抗体进行蛋白质印迹和流式细胞术，证明THBS1-CD47轴调控巨噬细胞线粒体功能，影响炎症反应和组织修复过程。

4. **"Antibody-based targeting of THBS1 enhances antitumor immunity in triple-negative breast cancer"**

*作者：Soto-Pantoja D.R. et al.*

摘要：开发靶向THBS1的中和抗体，在乳腺癌模型中阻断其免疫抑制功能，显著增强T细胞活性并抑制肿瘤生长，为临床转化提供依据。

注：以上文献为示例性质，实际引用时请核对原文信息及数据库(如PubMed)的准确性。

       

背景信息

**Background of THBS1 Antibody**

Thrombospondin-1 (THBS1), encoded by the *THBS1* gene, is a multifunctional extracellular matrix glycoprotein involved in cell adhesion, angiogenesis, immune regulation, and tissue remodeling. It interacts with receptors, cytokines, and growth factors (e.g., TGF-β, CD36. CD47) to modulate signaling pathways. THBS1 is implicated in pathologies like cancer, atherosclerosis, fibrosis, and diabetic complications, where it often exhibits dual roles—either promoting or inhibiting disease progression depending on context.

THBS1 antibodies are essential tools for studying its expression, localization, and function. These antibodies are generated using immunogenic peptides or recombinant THBS1 protein, available as monoclonal or polyclonal forms. Monoclonal antibodies offer high specificity, while polyclonal antibodies may detect multiple epitopes. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), ELISA, and flow cytometry to analyze THBS1 in tissues, cells, or biological fluids.

In research, THBS1 antibodies help elucidate its role in tumor suppression (e.g., anti-angiogenic effects) or disease exacerbation (e.g., promoting fibrosis). They also serve as potential biomarkers for cancer prognosis or therapeutic targeting. Commercial THBS1 antibodies are often validated for cross-reactivity across species (human, mouse, rat) and applications. However, variability in experimental outcomes may arise due to post-translational modifications or isoform-specific epitopes, emphasizing the need for rigorous validation.

Overall, THBS1 antibodies are pivotal in advancing mechanistic insights into THBS1-related pathways and their translational applications.

       
THBS1抗体;THBS1;THBS1 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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