NEK9抗体;NEK9 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P11518(NEK9 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P11518(NEK9 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

**Background of NEK9 Antibody**

NEK9 (NIMA-related kinase 9) is a serine/threonine kinase belonging to the NEK family, which plays critical roles in cell cycle regulation, particularly during mitosis. It is involved in key processes such as centrosome maturation, mitotic spindle assembly, and chromosome segregation. NEK9 functions upstream of NEK6 and NEK7. activating these kinases through phosphorylation, which are essential for mitotic progression. Dysregulation of NEK9 has been linked to genomic instability and is implicated in cancers, including breast, ovarian, and neuroblastoma, where its overexpression correlates with poor prognosis.

NEK9 antibodies are essential tools for studying its expression, localization, and function in cellular and disease contexts. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate NEK9's role in cell cycle checkpoints, its interaction with binding partners (e.g., BRCA1. HSP90), and its phosphorylation dynamics. Research utilizing NEK9 antibodies has also explored its potential as a therapeutic target, particularly in cancer, where kinase inhibitors or siRNA-mediated knockdown are being tested. These studies highlight NEK9's dual role as a regulator of mitotic fidelity and a contributor to oncogenic pathways, making it a focus of both basic and translational research.