NEK5抗体;NEK5 Antibody—艾普蒂

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse small intestines tissue lysate, Primary antibody: P13388(LRATD1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P13388(LRATD1 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

**Background of NEK5 Antibody**

NEK5 (NIMA-related kinase 5) belongs to the NEK family of serine/threonine kinases, which are implicated in cell cycle regulation, particularly in mitotic progression and DNA damage response. While other NEK family members, such as NEK2 and NEK6. are well-studied, NEK5 remains less characterized. Current evidence suggests NEK5 may play roles in centrosome maturation, cilia formation, and cellular stress responses. Its dysregulation has been tentatively linked to cancers, including breast and prostate cancer, though mechanistic insights remain limited.

NEK5 antibodies are critical tools for detecting and studying the expression, localization, and function of NEK5 in biological systems. These antibodies enable techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to explore NEK5's role in health and disease. Due to the kinase's low abundance and sequence homology with other NEKs, high specificity is essential for reliable results. Commercial NEK5 antibodies are typically validated for cross-reactivity and affinity to ensure accurate detection.

Research using NEK5 antibodies has begun uncovering its potential as a therapeutic target, particularly in oncology. However, gaps persist in understanding its substrates, signaling pathways, and regulatory mechanisms. Ongoing studies aim to clarify NEK5's contributions to cellular processes and pathologies, highlighting the antibody's importance in advancing molecular and clinical research.