PRKCB抗体;PRKCB Antibody—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal liver tissue, Primary antibody: P11497(PRKCB Antibody) at dilution 1/170, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes    

  
  

PRKCB (Protein Kinase C Beta) antibodies are essential tools in studying the function and expression of the PRKCB protein, a member of the protein kinase C (PKC) family. PKC enzymes are serine/threonine kinases involved in diverse cellular processes, including proliferation, differentiation, apoptosis, and immune responses. PRKCB, specifically, is a classical PKC isoform activated by calcium ions (Ca²⁺) and diacylglycerol (DAG), playing critical roles in signal transduction pathways such as NF-κB and MAPK. It is expressed in various tissues, with notable activity in the brain, immune cells, and vascular endothelium.

Research using PRKCB antibodies has linked this kinase to pathological conditions, including cancer (e.g., promoting tumor angiogenesis and metastasis), diabetic complications (e.g., retinopathy and nephropathy), and neurological disorders (e.g., Alzheimer’s disease). Antibodies targeting PRKCB are employed in techniques like Western blotting, immunohistochemistry, and flow cytometry to assess protein levels, cellular localization, and post-translational modifications. Some studies also explore PRKCB inhibition as a therapeutic strategy, underscoring the antibody's utility in drug development. Notably, PRKCB exists as two splice variants (βI and βII), and antibodies may differentiate between isoforms, aiding in isoform-specific functional studies. Careful validation is required to ensure specificity, given structural similarities among PKC family members.