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  • ARID2抗体;ARID2 Antibody—艾普蒂
  • ARID2抗体;ARID2 Antibody—艾普蒂
  • ARID2抗体;ARID2 Antibody—艾普蒂

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ARID2抗体;ARID2 Antibody—艾普蒂

Rabbit Polyclonal ARID2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-26

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：nuodina88@163.com

产品详情:

中文名称：
ARID2抗体
英文名称：
Rabbit Polyclonal ARID2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 6085 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
ARID2

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

Aliasesp200; BAF200
WB Predicted band size197 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human ARID2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: TM4 cell, Primary antibody: P11472(ARID2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11472(ARID2 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P11472(ARID2 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是3篇关于ARID2抗体的代表性文献(内容基于公开研究整理，部分信息为模拟示例)：

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1. **文献名称**: *ARID2 deficiency promotes hepatocellular carcinoma progression through impaired chromatin remodeling*

**作者**: Li, X. et al.

**摘要**: 本研究利用ARID2特异性抗体进行免疫组化和Western blot分析，发现ARID2在肝癌组织中表达显著下调，其缺失通过破坏SWI/SNF复合体功能导致促癌基因异常激活，加速肿瘤发展。

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2. **文献名称**: *ARID2 interacts with p53 to regulate DNA damage response in lung cancer*

**作者**: Wang, Y. et al.

**摘要**: 通过免疫共沉淀(ARID2抗体)和ChIP-seq技术，揭示ARID2与p53协同调控DNA损伤修复通路，ARID2缺失导致肺癌细胞对化疗耐药，提示其作为治疗靶点的潜力。

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3. **文献名称**: *Comprehensive analysis of ARID2 mutations in pancreatic cancer*

**作者**: Roberts, C.W. & Biegel, J.A.

**摘要**: 使用ARID2抗体进行免疫荧光和流式细胞术，系统分析胰腺癌中ARID2突变对染色质可及性的影响，发现突变导致细胞分化异常，与患者生存率下降相关。

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4. **文献名称**: *ARID2 modulates antiviral immunity via epigenetic regulation of interferon signaling*

**作者**: Chen, Z. et al.

**摘要**: 通过ARID2抗体介导的染色质免疫沉淀(ChIP)，证实ARID2通过重塑干扰素通路相关基因的染色质结构，调控先天免疫反应，为病毒感染相关疾病提供机制解释。

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注：以上文献为示例性内容，实际引用时请以PubMed或期刊官网的原文信息为准。

       

背景信息

The ARID2 (AT-rich interaction domain 2) antibody is a tool used to detect and study the ARID2 protein, a component of the SWI/SNF chromatin remodeling complex. This multi-subunit complex regulates gene expression by altering chromatin structure, enabling access to transcriptional machinery. ARID2. part of the PBAF (Polybromo-associated BAF) subfamily, contains an AT-rich DNA-binding domain and interacts with other subunits like BRG1 and BAF200. It plays roles in cell cycle control, differentiation, and tumor suppression by modulating target genes involved in these processes.

Research using ARID2 antibodies focuses on its involvement in cancer biology, as ARID2 mutations are linked to hepatocellular carcinoma, melanoma, and other malignancies. These mutations often disrupt SWI/SNF function, promoting genomic instability and oncogenesis. ARID2 antibodies are employed in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression levels, subcellular localization, and interactions in both normal and diseased tissues. Reduced ARID2 expression is frequently observed in tumors, suggesting its role as a potential tumor suppressor. Additionally, studies explore its interplay with signaling pathways (e.g., Wnt/β-catenin) and epigenetic regulation. ARID2 antibodies are critical for elucidating its diagnostic or therapeutic relevance in precision oncology.

       
ARID2抗体;ARID2;ARID2 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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