WNT1抗体;WNT1 Antibody—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 50 μg, Lane: HT29 cells, Primary antibody: P11470(WNT1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11470(WNT1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The WNT1 antibody is a crucial tool for studying the WNT1 protein, a member of the evolutionarily conserved Wnt family of signaling molecules. WNT1 plays a pivotal role in the Wnt/β-catenin (canonical) pathway, regulating embryonic development, cell proliferation, differentiation, and tissue homeostasis. It is particularly vital in central nervous system development, bone formation, and stem cell maintenance. Dysregulation of WNT1 is linked to diseases such as osteoporosis, neurodegenerative disorders, and cancers (e.g., breast cancer, melanoma).

WNT1 antibodies are widely used in research to detect and quantify WNT1 expression in tissues or cells via techniques like Western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF). They help elucidate WNT1’s spatial-temporal expression patterns, interaction partners, and signaling mechanisms. Some antibodies neutralize WNT1 activity, enabling functional studies to dissect its role in development or disease.

Commercially available WNT1 antibodies vary in specificity, targeting different epitopes (e.g., N-terminal, C-terminal). Validation across species (human, mouse, rat) and applications is critical due to potential cross-reactivity with other Wnt family members. Recent studies explore therapeutic potential, with WNT1-targeting antibodies investigated for cancer treatment or regenerative medicine. However, challenges remain, including pathway complexity and off-target effects. Overall, WNT1 antibodies remain indispensable for advancing both basic research and clinical translation in Wnt-related biology.