APOL2抗体;APOL2 Antibody—艾普蒂

The APOL2 (Apolipoprotein L2) antibody is a tool used to detect and study the APOL2 protein, part of the apolipoprotein L family involved in lipid metabolism and innate immunity. APOL proteins, primarily APOL1-6. are expressed in various tissues and play roles in intracellular vesicle trafficking, autophagy, and apoptosis. While APOL1 is well-characterized for its association with kidney disease risk variants in populations of African ancestry, APOL2 remains less understood. APOL2 shares structural homology with APOL1. including conserved lipid-binding and ion-channel domains, but lacks the C-terminal SRA-interacting domain critical for APOL1's trypanolytic activity. Research suggests APOL2 may compensate for APOL1 functions in specific contexts, influencing cellular stress responses and pathogen defense. Antibodies against APOL2 enable investigations into its expression patterns, subcellular localization (e.g., endoplasmic reticulum, Golgi), and interactions with other proteins. Recent studies explore its potential role in metabolic disorders, viral resistance, and cancer biology. However, functional insights remain limited compared to APOL1. necessitating further research to clarify its physiological and pathological significance. Commercial APOL2 antibodies are typically validated for applications like Western blotting, immunohistochemistry, and immunofluorescence in human and model organism samples.