ANKZF1抗体;ANKZF1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P11457(ANKZF1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The ANKZF1 (Ankyrin Repeat and Zinc Finger Domain Containing 1) antibody is a tool used to study the ANKZF1 protein, a less characterized molecule implicated in cellular processes like protein homeostasis and mitochondrial quality control. ANKZF1 contains ankyrin repeats, which mediate protein-protein interactions, and a zinc finger domain, often associated with nucleic acid binding or structural roles. Studies suggest its involvement in regulating proteasome-mediated protein degradation, potentially acting as a chaperone or adaptor for damaged proteins.

ANKZF1 has drawn attention in cancer research due to its altered expression in certain tumors, though its role remains context-dependent, showing both oncogenic and tumor-suppressive traits in different models. It may also interact with pathways linked to neurodegeneration, particularly those involving mitochondrial dysfunction, such as the PINK1/Parkin-mediated mitophagy pathway.

The ANKZF1 antibody enables detection and localization of the protein via techniques like Western blotting, immunohistochemistry, or immunofluorescence. Researchers use it to explore ANKZF1's expression patterns, subcellular distribution (e.g., cytosolic or mitochondrial associations), and interactions under stress conditions. Its development supports investigations into diseases involving proteostasis imbalance, such as cancer, neurodegenerative disorders, or aging-related pathologies. However, further validation of its specificity and functional relevance in diverse biological contexts is ongoing.