AMPD1抗体;AMPD1 Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal muscle tissue, Primary antibody: P11452(AMPD1 Antibody) at dilution 1/1600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11452(AMPD1 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11452(AMPD1 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

The AMPD1 antibody targets adenosine monophosphate deaminase 1 (AMPD1), a key enzyme in purine metabolism that catalyzes the conversion of adenosine monophosphate (AMP) to inosine monophosphate (IMP), with the release of ammonia. Primarily expressed in skeletal muscle, heart, and brain, AMPD1 plays a critical role in energy homeostasis by regulating adenosine nucleotide levels during high-energy demand or metabolic stress. Its activity influences cellular processes such as ATP regeneration, muscle contraction, and nitrogen metabolism.

AMPD1 deficiency, linked to inherited mutations, is associated with exercise intolerance, muscle cramps, and myopathy. Research also implicates AMPD1 in cardiovascular diseases, including heart failure, where altered enzyme activity may impact cardiac energy metabolism. Additionally, AMPD1 has been studied in cancer due to its role in metabolic reprogramming, a hallmark of tumor progression.

The AMPD1 antibody is widely used in biomedical research to detect protein expression levels via techniques like Western blotting, immunohistochemistry, or immunofluorescence. It aids in elucidating AMPD1's tissue-specific functions, disease mechanisms, and potential therapeutic targets. Commercial AMPD1 antibodies are typically validated for specificity and sensitivity, though variability in isoforms or post-translational modifications may require careful experimental design. Continued interest in AMPD1 stems from its dual role as a metabolic regulator and biomarker in neuromuscular and cardiovascular pathologies.