AKT2抗体;AKT2 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P11435(AKT2 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P11435(AKT2 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

**Background of AKT2 Antibody**

The AKT2 antibody is a crucial tool for studying the protein kinase AKT2 (also known as protein kinase B beta), a member of the AKT serine/threonine kinase family. AKT2 plays a central role in the PI3K/AKT/mTOR signaling pathway, which regulates cell survival, proliferation, metabolism, and apoptosis. Among the three AKT isoforms (AKT1. AKT2. AKT3), AKT2 is particularly associated with insulin signaling and glucose homeostasis, with strong implications in metabolic disorders like diabetes and cancer. Dysregulation of AKT2 is linked to tumor progression, chemotherapy resistance, and aberrant cell growth in cancers such as ovarian, pancreatic, and breast carcinomas.

AKT2 antibodies are designed to detect and quantify AKT2 expression, phosphorylation status (e.g., at Ser474 or Thr309), or localization in tissues and cell lines. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Phospho-specific AKT2 antibodies help assess pathway activation, aiding research into targeted therapies or resistance mechanisms.

Due to high sequence homology among AKT isoforms, antibody specificity is critical. Validation via knockout cell lines or siRNA-mediated knockdown ensures minimal cross-reactivity. Clinically, AKT2 antibodies contribute to biomarker studies, exploring correlations between AKT2 overexpression and disease prognosis. Their role in elucidating AKT2's dual function in oncology and metabolism underscores their importance in both basic research and therapeutic development.