ADH1B抗体;ADH1B Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Raji cell lysate, Primary antibody: P11433(ADH1B Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P11433(ADH1B Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

The ADH1B antibody is a crucial tool for studying alcohol dehydrogenase 1B (ADH1B), an enzyme encoded by the ADH1B gene in humans. ADH1B belongs to the alcohol dehydrogenase family, which catalyzes the oxidation of ethanol to acetaldehyde in the liver, playing a central role in alcohol metabolism. The ADH1B enzyme exhibits genetic polymorphisms, particularly the ADH1B*2 variant, which is associated with faster ethanol conversion and lower risk of alcohol dependence in certain populations.

ADH1B antibodies are widely used in research to detect and quantify ADH1B protein expression in tissues, notably in liver, stomach, and cancer studies. These antibodies enable techniques like Western blotting, immunohistochemistry (IHC), and ELISA to explore ADH1B's role in alcohol-related diseases, carcinogenesis, and metabolic disorders. For instance, reduced ADH1B expression has been linked to gastrointestinal cancers, while its overexpression may influence alcohol sensitivity.

Researchers also employ ADH1B antibodies to investigate tissue-specific expression patterns and genetic variations across ethnic groups. Both polyclonal and monoclonal versions are available, with selection depending on experimental needs for specificity and cross-reactivity. Validation parameters, including knockout controls and epitope mapping, ensure reliability in detecting this 40 kDa protein. Such studies contribute to understanding individual differences in alcohol metabolism and disease susceptibility.