TADA2A抗体;TADA2A Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P11422(TADA2A Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P11422(TADA2A Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The TADA2A (Transcriptional Adaptor 2A) antibody is a tool used to study the TADA2A protein, a key component of the human SAGA (Spt-Ada-Gcn5 acetyltransferase) complex. TADA2A functions as a transcriptional coactivator, facilitating chromatin remodeling and histone acetylation via its interaction with histone acetyltransferases like GCN5. It plays a critical role in regulating gene expression, DNA repair, and cellular responses to stress. Dysregulation of TADA2A has been linked to developmental disorders, such as GAND syndrome (global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies), and cancer progression.

TADA2A antibodies are typically developed in immunized hosts (e.g., rabbits or mice) using peptide antigens derived from conserved regions of the human TADA2A protein. These antibodies are validated for applications like Western blotting (WB), immunofluorescence (IF), and immunoprecipitation (IP). Specific clones or polyclonal preparations are commercially available from suppliers such as Santa Cruz Biotechnology, Abcam, and Cell Signaling Technology.

Researchers use TADA2A antibodies to investigate its role in chromatin dynamics, transcriptional regulation, and disease mechanisms. Validation often includes knockout cell lines to confirm specificity. Cross-reactivity with homologs in model organisms (e.g., mice) is sometimes assessed for translational studies. Proper controls, such as isotype-matched antibodies and antigen-blocking experiments, are essential to ensure reliable results.