ABCA4抗体;ABCA4 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P11416(ABCA4 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11416(ABCA4 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The ABCA4 antibody targets the ATP-binding cassette sub-family A member 4 (ABCA4) protein, a transmembrane transporter primarily expressed in photoreceptor cells of the retina. ABCA4 plays a critical role in the visual cycle by facilitating the clearance of retinoid derivatives, such as N-retinylidene-phosphatidylethanolamine, from photoreceptor discs. Mutations in the ABCA4 gene are the leading cause of autosomal recessive Stargardt disease, a juvenile-onset macular degeneration characterized by lipid-rich lipofuscin accumulation and progressive vision loss. Additionally, ABCA4 variants are linked to cone-rod dystrophy and retinitis pigmentosa.

ABCA4 antibodies are essential tools for studying the protein's expression, localization, and functional abnormalities in disease models. They enable researchers to investigate ABCA4's role in retinal homeostasis, its interaction with visual cycle components, and the pathological mechanisms underlying ABCA4-associated disorders. These antibodies are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to assess protein levels in retinal tissues or cellular models.

Recent therapeutic efforts, including gene therapy and small-molecule correctors, aim to restore ABCA4 function. ABCA4 antibodies aid in validating these approaches by monitoring protein expression and trafficking. Their development continues to advance diagnostic precision and mechanistic insights into retinal degenerative diseases, highlighting their importance in both basic research and clinical applications.