CELSR2抗体;CELSR2 Antibody—艾普蒂

The CELSR2 (Cadherin EGF LAG Seven-Pass G-Type Receptor 2) antibody is a tool used to detect and study the CELSR2 protein, a member of the non-clustered protocadherin family within the cadherin superfamily. CELSR2 is a key component of the planar cell polarity (PCP) pathway, which regulates tissue organization and cell orientation during embryonic development. It plays critical roles in neural tube closure, cardiovascular development, and tissue morphogenesis by mediating cell-cell adhesion and signaling. Dysregulation of CELSR2 has been implicated in congenital disorders, cancers, and neurodevelopmental conditions. The antibody specifically targets epitopes of CELSR2. enabling researchers to investigate its expression, localization, and interactions in various biological contexts. It is widely used in techniques like Western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. Validation of CELSR2 antibodies often includes knockout controls or siRNA-based silencing to confirm specificity. Commercial sources offer monoclonal and polyclonal variants, with applications spanning developmental biology, oncology, and neuroscience research. Proper validation ensures reliability in both research and diagnostic settings, aiding mechanistic studies of CELSR2-associated pathways and pathologies.