LPAR1抗体;LPAR1 Antibody—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: A375 cells, Primary antibody: P11399(LPAR1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11399(LPAR1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The lysophosphatidic acid receptor 1 (LPAR1), a G protein-coupled receptor (GPCR) belonging to the endothelial differentiation gene (EDG) family, mediates cellular responses to lysophosphatidic acid (LPA), a bioactive phospholipid involved in diverse physiological and pathological processes. LPAR1 plays critical roles in cell proliferation, migration, and survival, with implications in cancer progression, fibrosis, inflammation, and neurological disorders. Antibodies targeting LPAR1 are valuable tools for studying its expression, activation mechanisms, and signaling pathways in both normal and diseased tissues.

LPAR1 antibodies are widely used in techniques like immunohistochemistry (IHC), Western blotting, and flow cytometry to map receptor localization and quantify expression levels in preclinical models or clinical samples. Dysregulation of LPAR1 has been observed in cancers (e.g., ovarian, breast), fibrotic diseases (e.g., pulmonary, renal fibrosis), and neurodegenerative conditions, making it a potential therapeutic target. Researchers also employ LPAR1-neutralizing antibodies to inhibit LPA-induced signaling cascades, exploring their therapeutic potential in blocking tumor metastasis or fibrotic remodeling. Recent studies focus on developing monoclonal antibodies with high specificity to advance diagnostic assays or targeted therapies. Additionally, LPAR1 antibodies contribute to elucidating receptor-ligand interactions and downstream effectors, aiding drug discovery efforts for small-molecule antagonists. Their utility extends to biomarker research, as LPAR1 overexpression often correlates with disease severity and prognosis.