TNN抗体;TNN Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11376(TNN Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P11376(TNN Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

**Background of TNN Antibody**

Tenascin-N (TNN), a lesser-studied member of the tenascin family of extracellular matrix glycoproteins, is encoded by the *TNN* gene in humans. Tenascins are known for their roles in tissue development, cell adhesion, and modulation of signaling pathways. TNN shares structural features with other tenascins, including epidermal growth factor (EGF)-like repeats, fibronectin type III domains, and a fibrinogen-like globular domain, which mediate interactions with cellular receptors and extracellular components.

While tenascin-C (TNC) is widely recognized for its involvement in cancer, inflammation, and tissue repair, TNN has distinct expression patterns and functions. It is predominantly expressed in the nervous system, particularly during embryogenesis, suggesting a role in neural development and synaptic plasticity. Recent studies also implicate TNN in regulating cell migration, proliferation, and differentiation in specific tissues.

TNN antibodies are tools used to detect and study the spatial-temporal distribution and functional mechanisms of TNN in biological systems. Dysregulation of TNN has been linked to neurological disorders, autoimmune diseases, and certain cancers, though its precise pathological roles remain under investigation. In research, TNN antibodies enable immunohistochemical staining, Western blotting, and functional blocking experiments, aiding in the exploration of TNN's interactions with integrins or other receptors.

The development of TNN-specific antibodies has potential clinical applications, including diagnostic biomarkers or therapeutic targets for diseases associated with extracellular matrix remodeling. Further studies are needed to clarify its tissue-specific functions and therapeutic relevance.