SOX8抗体;SOX8 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P11354(SOX8 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The SOX8 antibody is a crucial tool for studying the SOX8 protein, a member of the SRY-related HMG-box (SOX) transcription factor family. SOX8 plays pivotal roles in embryonic development, cell differentiation, and tissue homeostasis, particularly in the nervous system, gonads, and neural crest-derived tissues. It shares functional redundancy with SOX9 and SOX10. often participating in overlapping pathways, such as sex determination, gliogenesis, and melanocyte development. Dysregulation of SOX8 has been linked to diseases like glioblastoma, melanoma, and colorectal cancer, as well as disorders of sexual development.

SOX8 antibodies are widely used in research to detect protein expression, localization, and dynamics via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help elucidate SOX8's role in maintaining stem cell pluripotency, regulating tumor progression, or mediating neural crest cell migration. Recent studies also highlight SOX8 mutations in 46.XX testicular disorders and its interaction with signaling pathways like Wnt/β-catenin.

Validated for specificity in human and mouse models, SOX8 antibodies are essential for comparative studies across species. Researchers rely on them to explore SOX8's tissue-specific functions, epigenetic regulation, and potential as a diagnostic or therapeutic biomarker in oncology and developmental biology.