SLC9A7抗体;SLC9A7 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P11353(SLC9A7 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The SLC9A7 antibody is a research tool designed to detect and study the solute carrier family 9 member A7 (SLC9A7) protein, a Na⁺/H⁺ exchanger primarily localized to the Golgi apparatus and early endosomes. This protein plays a critical role in regulating intracellular pH and ion homeostasis, which is essential for organelle function, membrane trafficking, and cellular processes like secretion and autophagy. SLC9A7 is linked to X-linked intellectual disability (XLID) and other disorders, with mutations potentially disrupting Golgi acidification and impairing neuronal development.

The antibody is commonly used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to analyze SLC9A7 expression, localization, and interactions in various tissues or disease models. Its specificity is validated through knockout controls or siRNA knockdown experiments. Research applications include exploring SLC9A7's role in cancer progression, neurological disorders, and cellular stress responses. Commercial SLC9A7 antibodies are typically polyclonal or monoclonal, raised in hosts like rabbits or mice, and require optimization for experimental conditions. Ongoing studies aim to clarify its molecular mechanisms and therapeutic potential in associated diseases.