SCN10A抗体;SCN10A Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P11337(SCN10A Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P11337(SCN10A Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

SCN10A, also known as Nav1.8. is a voltage-gated sodium channel encoded by the SCN10A gene. It is primarily expressed in peripheral sensory neurons, particularly in nociceptive neurons of the dorsal root ganglia (DRG) and cardiac neurons. Nav1.8 plays a critical role in mediating action potential propagation in pain-sensing neurons and contributes to cardiac electrophysiology. Dysregulation of SCN10A has been implicated in neuropathic pain, cardiac arrhythmias, and other disorders.

SCN10A antibodies are immunological tools designed to detect and study the expression, localization, and function of the Nav1.8 protein. These antibodies are widely used in research to investigate pain pathways, cardiac conduction abnormalities, and potential therapeutic targets. For example, they help identify SCN10A expression changes in chronic pain models or analyze its role in sodium current modulation in cardiomyocytes. Validation of SCN10A antibodies is crucial, as cross-reactivity with other sodium channel isoforms (e.g., Nav1.7 or Nav1.9) can occur due to structural similarities. Applications include Western blotting, immunohistochemistry, and immunofluorescence in both human and rodent tissues. Recent studies also explore SCN10A's association with human genetic variants linked to altered pain perception or arrhythmia risk, further driving demand for reliable antibodies. Proper utilization of these reagents advances understanding of sodium channel biology and supports drug discovery for pain management and cardiovascular diseases.