PTPRM抗体;PTPRM Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P11328(PTPRM Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P11328(PTPRM Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

The protein tyrosine phosphatase receptor type M (PTPRM) is a member of the receptor-type PTP family, which plays critical roles in regulating cellular signaling by dephosphorylating tyrosine residues. PTPRM is characterized by a unique extracellular domain containing fibronectin type III-like repeats and a single intracellular catalytic phosphatase domain. It is involved in homophilic cell-cell adhesion and modulates intracellular signaling pathways that control cell growth, differentiation, and migration. Dysregulation of PTPRM has been implicated in various diseases, including cancer, neurological disorders, and autoimmune conditions, highlighting its importance in maintaining cellular homeostasis.

Antibodies targeting PTPRM are essential tools for investigating its expression, localization, and functional mechanisms. These antibodies enable the detection of PTPRM in tissues or cell lines via techniques like Western blotting, immunohistochemistry, and flow cytometry. They also facilitate studies on PTPRM's role in signal transduction, particularly its interactions with adhesion molecules (e.g., cadherins) and growth factor receptors. Recent research has explored PTPRM's dual role as both a tumor suppressor and promoter, depending on cellular context, making its antibodies valuable for cancer biomarker studies. Additionally, PTPRM antibodies contribute to understanding synaptic plasticity and neural development, as the protein is enriched in neuronal tissues. Ongoing efforts focus on developing highly specific monoclonal antibodies to improve diagnostic and therapeutic applications, particularly in targeting PTPRM-related pathways in disease models.