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PTEN抗体;PTEN Antibody—艾普蒂

Rabbit Polyclonal PTEN Antibody

询价 20μl 起订

50μl 起订

100μl 起订

上海更新日期：2025-05-25

上海切尔齐生物科技有限公司

VIP1年

联系人：周经理

电话：027-19371278702拨打

手机：18008634902 拨打

邮箱：nuodina88@163.com

产品详情:

中文名称：: PTEN抗体

英文名称：: Rabbit Polyclonal PTEN Antibody

品牌：: 艾普蒂

产地：: 武汉

保存条件：: Stored at -20°C for 5999 year. Avoid repeated freeze / thaw cycles.

产品类别：: 抗体

重组：: 否

应用：: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA

种属反应性：: Human,Mouse,Rat

宿主：: Rabbit

偶联物：: 无

靶点：: PTEN

验证与应用

应用及物种

WB	咨询技术	Human,Mouse,Rat
IF	咨询技术	Human,Mouse,Rat
IHC	1/25-1/50	Human,Mouse,Rat
ICC	技术咨询	Human,Mouse,Rat
FCM	咨询技术	Human,Mouse,Rat
Elisa	1/500-1/1000	Human,Mouse,Rat

产品详情

Aliases	BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; PTENbeta
WB Predicted band size	47 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	Synthetic peptide of human PTEN
Formulation	Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: NIH/3T3 and 293T cell lysates, Primary antibody: P11326(PTEN Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 5 minutes
The image is immunohistochemistry of paraffin-embedded Human brain tissue using P11326(PTEN Antibody) at dilution 1/50. (Original magnification: ×200)

参考文献

以下是3篇与PTEN抗体相关的经典文献示例(内容为虚构简化，仅供参考)：

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1. **文献名称**: "Comprehensive characterization of PTEN monoclonal antibodies for specificity and sensitivity in clinical diagnostics"

**作者**: Li J. et al.

**摘要**: 比较了多种市售PTEN抗体的特异性，通过Western blot和免疫组化验证其在癌症组织中的检测可靠性，发现部分抗体存在非特异性结合问题，推荐了两种高特异性抗体用于临床样本分析。

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2. **文献名称**: "PTEN expression loss in glioblastoma: Validation of a novel antibody for immunohistochemical analysis"

**作者**: Wang H. et al.

**摘要**: 开发了一种新型PTEN抗体，优化了染色条件，证实其在胶质母细胞瘤中检测PTEN蛋白缺失的敏感性，并与基因测序结果高度一致，为肿瘤分子分型提供可靠工具。

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3. **文献名称**: "Antibody cross-reactivity in PTEN knockout models: Implications for precision research"

**作者**: Martinez R. et al.

**摘要**: 揭示了部分PTEN抗体在小鼠模型中的交叉反应性，强调抗体验证在基因敲除研究中的必要性，提出标准化实验流程以避免假阳性结果。

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4. **文献名称**: "PTEN antibody-based biosensors for real-time monitoring of cellular signaling"

**作者**: Chen L. et al.

**摘要**: 利用高亲和力PTEN抗体开发了新型生物传感器，成功实时追踪PTEN蛋白动态变化，揭示了其在PI3K/AKT通路调控中的快速响应机制。

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(注：以上为模拟文献，实际引用请通过PubMed或学术数据库检索真实研究。)

背景信息

PTEN (phosphatase and tensin homolog) is a critical tumor suppressor gene that encodes a dual-specificity phosphatase protein involved in regulating cell growth, proliferation, and survival. The PTEN protein primarily antagonizes the PI3K/AKT/mTOR signaling pathway by dephosphorylating phosphatidylinositol (3.4.5)-trisphosphate (PIP3), thereby maintaining cellular homeostasis. Loss or mutation of PTEN is linked to various cancers, metabolic disorders, and neurological conditions, making it a key focus in biomedical research.

PTEN antibodies are essential tools for detecting and quantifying PTEN expression in experimental and clinical settings. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to study PTEN localization, expression levels, and post-translational modifications. Specific PTEN antibodies target distinct epitopes, such as the N-terminal phosphatidylinositol phosphate-binding domain or the C-terminal regulatory region, allowing researchers to explore structural and functional aspects of the protein.

Validating PTEN antibodies is crucial due to potential cross-reactivity with pseudogenes or homologous proteins. High-quality antibodies are characterized by specificity, sensitivity, and reproducibility across sample types, including formalin-fixed tissues or cell lysates. Clinically, PTEN antibody-based assays aid in diagnosing PTEN-related syndromes (e.g., PTEN hamartoma tumor syndrome) and assessing cancer prognosis. Ongoing research continues to refine PTEN antibody applications, supporting advances in targeted therapies and personalized medicine.

PTEN抗体;PTEN;PTEN Antibody;

公司简介

生物技术有限公司

成立日期	(2年)
注册资本	20万人民币
员工人数	1-10人
年营业额	￥ 100万以内
经营模式	贸易,工厂,试剂,定制,服务
主营行业	抗体,植物生物技术,细胞培养,蛋白组学