PDIA2抗体;PDIA2 Antibody—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P11315(PDIA2 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P11315(PDIA2 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The PDIA2 antibody targets Protein Disulfide Isomerase Family A Member 2 (PDIA2), a member of the protein disulfide isomerase (PDI) family. PDIA2. also known as PDIR, is an endoplasmic reticulum (ER)-resident oxidoreductase involved in catalyzing disulfide bond formation, isomerization, and reduction during protein folding. It plays a critical role in maintaining ER homeostasis by assisting in the proper folding of secretory and membrane proteins, particularly in high-secreting cells like pancreatic, intestinal, or immune cells. Structurally, PDIA2 contains thioredoxin-like domains with catalytic CXXC motifs essential for its enzymatic activity.

PDIA2 expression is often upregulated under ER stress conditions, linking it to diseases such as cancer, diabetes, and inflammatory disorders. Studies suggest its involvement in modulating immune responses, including antigen presentation and cytokine production. The PDIA2 antibody is widely used in research to investigate protein folding mechanisms, ER stress pathways, and disease-associated dysregulation. Applications include Western blotting, immunohistochemistry, and immunofluorescence to localize PDIA2 in tissues or cells. Its specificity and validation are crucial for distinguishing PDIA2 from other PDI family members, which share structural similarities but exhibit distinct functional roles. Recent research also explores PDIA2 as a potential therapeutic target or biomarker in pathologies linked to proteostasis imbalance.