PLPPR5抗体;PLPPR5 Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: HepG2 and A172 cell lysates, Primary antibody: P11307(PLPPR5 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P11307(PLPPR5 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The PLPPR5 (Phospholipid Phosphatase-Related 5) antibody is a tool used to study the PLPPR5 protein, a member of the phospholipid phosphatase-related protein family. PLPPR5. also known as plasticity-related gene 5 (PRG5), is a transmembrane protein implicated in lipid phosphate phosphatase activity, influencing lipid signaling and membrane dynamics. It is predominantly expressed in the central nervous system, particularly in neurons, where it regulates synaptic plasticity, neurite outgrowth, and neural circuit formation. PLPPR5 interacts with lysophosphatidic acid (LPA), a bioactive lipid mediator, modulating its extracellular levels and downstream signaling pathways involved in neurodevelopment, inflammation, and pain perception.

Antibodies targeting PLPPR5 enable researchers to investigate its expression patterns, subcellular localization, and functional roles in both physiological and pathological contexts. Studies using PLPPR5 antibodies have linked the protein to neurological disorders, including epilepsy, schizophrenia, and neuropathic pain, as well as cancer progression due to its role in cell migration and invasion. These antibodies are widely applied in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to explore PLPPR5's involvement in disease mechanisms or therapeutic targets. Ongoing research aims to clarify its precise molecular interactions and potential as a biomarker or drug candidate.