NOTCH3抗体;NOTCH3 Antibody—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: MCF7 cell lysate, Primary antibody: P11288(NOTCH3 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P11288(NOTCH3 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P11288(NOTCH3 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

NOTCH3 antibodies are tools used to study the NOTCH3 protein, a transmembrane receptor crucial for cell-cell signaling and vascular homeostasis. NOTCH3 is predominantly expressed in vascular smooth muscle cells (VSMCs) and pericytes, where it regulates cell differentiation, proliferation, and survival. Mutations in the NOTCH3 gene are linked to cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a hereditary stroke disorder characterized by VSMC degeneration, cerebral small vessel pathology, and cognitive decline. These mutations often affect epidermal growth factor-like (EGF) repeats in the extracellular domain, leading to protein aggregation and vascular dysfunction.

NOTCH3 antibodies target specific regions of the protein, such as the extracellular EGF repeats or intracellular domains, enabling researchers to detect expression levels, localization, or pathological aggregates in tissues or cell models. They are widely used in immunohistochemistry, Western blotting, and immunofluorescence to investigate NOTCH3-related mechanisms in CADASIL and other vascular or neurodegenerative diseases. Additionally, these antibodies aid in developing diagnostic assays and exploring therapeutic strategies, such as blocking abnormal signaling or clearing toxic protein deposits. Recent studies also explore NOTCH3's role beyond CADASIL, including cancer and age-related vascular disorders, highlighting its broader implications in cellular signaling pathways.