NEUROG1抗体;NEUROG1 Antibody—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: 293T, HepG2, A375 cell lysates, Primary antibody: P11281(NEUROG1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11281(NEUROG1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The NEUROG1 antibody is a tool used to detect Neurogenin 1 (NEUROG1), a transcription factor critical in neural development. NEUROG1 belongs to the basic helix-loop-helix (bHLH) family and acts as a "proneural" gene, driving the differentiation of progenitor cells into neurons. It is particularly vital in specifying sensory neurons, inner ear hair cells, and subsets of cranial ganglia during embryogenesis. By binding to E-box DNA sequences, NEUROG1 activates downstream genes that commit cells to neural lineages while suppressing alternative fates.

Antibodies targeting NEUROG1 are essential in research to visualize its expression patterns, study regulatory mechanisms, or assess its role in disease models. They are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence, enabling localization and quantification of NEUROG1 in tissues or cultured cells. Such studies have linked NEUROG1 dysregulation to neurodevelopmental disorders, hearing loss, and cancers like neuroblastoma.

Recent work also explores NEUROG1's potential in regenerative medicine, particularly in reprogramming non-neural cells into neurons. However, antibody specificity remains a consideration, as cross-reactivity with related bHLH proteins (e.g., NEUROG2/3) can occur. Validation via knockout controls or epitope mapping is often recommended. Overall, NEUROG1 antibodies continue to advance our understanding of neural differentiation and pathological mechanisms, bridging developmental biology and therapeutic innovation.