DDR2抗体;DDR2 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11248(DDR2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

**Background of DDR2 Antibodies**

DDR2 (Discoidin Domain Receptor 2) is a transmembrane tyrosine kinase receptor that binds collagen to regulate cell adhesion, proliferation, and extracellular matrix remodeling. It plays critical roles in development, tissue homeostasis, and pathological processes such as fibrosis, cancer, and osteoarthritis. DDR2 antibodies are immunological tools designed to detect, quantify, or inhibit DDR2 in experimental and clinical settings.

These antibodies are essential for studying DDR2’s signaling mechanisms, including its activation by collagen ligands and downstream pathways (e.g., MAPK, PI3K/AKT). In cancer research, DDR2 antibodies help investigate its dual role as both a tumor suppressor and promoter, depending on context. Overexpression or mutations in DDR2 are linked to tumor progression, metastasis, and therapy resistance, making it a potential therapeutic target.

DDR2 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to assess protein expression in tissues or cell lines. Some therapeutic antibodies are also being explored to block aberrant DDR2 signaling in diseases. Challenges include ensuring specificity due to structural similarities with DDR1. a related receptor. Validated DDR2 antibodies are critical for advancing research in fibrosis, cancer biology, and regenerative medicine, offering insights into targeted therapies and diagnostic biomarkers.