ESR2抗体;ESR2 Antibody—艾普蒂

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: 231, K562, PC-3, A172 and A549 cell lysates, Primary antibody: P10838(ESR2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10838(ESR2 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The estrogen receptor 2 (ESR2), also known as ERβ, is a nuclear receptor that mediates the biological effects of estrogen by regulating gene expression. It shares structural similarities with ESR1 (ERα) but differs in tissue distribution and functional roles. ESR2 is widely expressed in reproductive tissues, bone, cardiovascular and central nervous systems, and immune cells, playing key roles in cell proliferation, differentiation, and homeostasis. Its involvement in hormone-responsive cancers (e.g., breast, ovarian, prostate), metabolic disorders, and neurodegenerative diseases has driven research interest.

ESR2 antibodies are critical tools for detecting and quantifying ESR2 protein levels in research and diagnostics. They enable the study of ESR2 expression patterns, subcellular localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help elucidate ESR2's context-dependent roles, particularly its contrasting or complementary effects to ESR1 in diseases. For example, ESR2 may act as a tumor suppressor in certain cancers, influencing therapeutic responses and prognosis. However, challenges persist in antibody specificity due to ESR2's multiple isoforms and post-translational modifications, which can lead to variability in experimental outcomes. Validated ESR2 antibodies remain essential for advancing studies on estrogen signaling pathways and developing targeted therapies for hormone-related conditions.