DHTKD1抗体;DHTKD1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P10605(DHTKD1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10605(DHTKD1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The DHTKD1 antibody is a tool used to study the dehydrogenase E1 and transketolase domain-containing 1 (DHTKD1) protein, encoded by the DHTKD1 gene. This mitochondrial protein is part of the 2-oxoacid dehydrogenase family, playing a role in lysine and tryptophan metabolism by catalyzing oxidative decarboxylation of α-ketoadipate. DHTKD1 is linked to the 2-oxoadipate dehydrogenase complex, contributing to cellular energy production and metabolite homeostasis.

Mutations in DHTKD1 are associated with 2-aminoadipic 2-oxoadipic aciduria (AMOXAD), a rare metabolic disorder characterized by elevated 2-aminoadipic and 2-oxoadipic acid levels, and possibly neuropathy. Studies also suggest a connection to Charcot-Marie-Tooth disease type 2. highlighting its role in peripheral nerve function.

The DHTKD1 antibody aids in detecting protein expression, localization, and quantification via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It is valuable for exploring DHTKD1’s physiological roles, disease mechanisms, and interactions with metabolic pathways. Researchers utilize species-specific (human, mouse, rat) monoclonal or polyclonal antibodies to investigate tissue distribution, mitochondrial dysfunction, and mutation impacts. Its applications span basic research, clinical diagnostics, and therapeutic target validation in metabolic and neurodegenerative disorders.