KLC2抗体;KLC2 Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human cerebrum tissue and Mouse brain tissue lysates, Primary antibody: P10201(KLC2 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10201(KLC2 Antibody) at dilution 1/120. (Original magnification: ×200)    

  
  

**Background of KLC2 Antibody**

The KLC2 (kinesin light chain 2) antibody is a research tool designed to detect and study the KLC2 protein, a component of the kinesin-1 motor complex. Kinesins are microtubule-dependent motor proteins critical for intracellular transport, facilitating the movement of cargoes like organelles, vesicles, and protein complexes along microtubules. KLC2. one of several kinesin light chain isoforms, plays a role in binding cargoes and regulating the activity of the kinesin heavy chain (KHC).

KLC2 is particularly studied in neuronal and non-neuronal cells for its involvement in axonal transport, cell division, and maintaining cellular architecture. Dysregulation of KLC2 has been linked to neurodegenerative diseases (e.g., Alzheimer’s, Huntington’s) and cancer, where altered intracellular transport may contribute to disease progression.

Antibodies targeting KLC2 enable researchers to investigate its expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. These studies help elucidate KLC2’s functional roles and mechanisms in health and disease. Commercial KLC2 antibodies are typically raised in hosts like rabbits or mice, with specificity validated using knockout controls or siRNA-mediated depletion.

Overall, the KLC2 antibody serves as a vital reagent in exploring the molecular basis of intracellular transport and its pathological disruptions.